Therapy advantages

Schematic graph of weekly clearances
Schematic graph of weekly clearances

HighVolumeHDF® with its numerous positive effects on dialysis-related cardiovascular risk factors is acknowledged as the most effective dialysis treatment modality1, coming closer to the elimination profile of the natural kidney.

By achieving high substitution volumes, HighVolumeHDF® therapy is credited with more effective elimination of middle molecules. HighVolumeHDF® improves patient outcomes and exerts beneficial effects on the main cardiovascular risk factors:

  • Serum ß2-m and phosphate level2,3,4
  • Inflammatory response5
  • Intradialytic haemodynamic stability6
  • Anaemia control7

These factors contribute to better quality of life and improved patient survival.8

1 Krick G, Ronco C (eds), Contrib Nephrol. (2011); 175: 93-109.
2 Canaud B., Contrib Nephrol (2007); 158: 216-224.
3 Penne L. et al., Clin J Am Soc Nephrol (2010); 5: 80-86.
4 Davenport A., Nephrol Dial Transplant (2010); 25: 897-901.
5 Pedrini L. et al., Nephrol Dial Transplant, advanced access published Jan 18, 2011.
6 Locatelli F. et al., J Am Soc Nephrol (2010); 21: 1798-1807.
7 Bonforte G. et al., Blood Purif (2002); 20: 357-363.
8 Maduell F. et al., J Am Soc Nephrol (2013); 24: 487-497.

Reduced mortality risk with HighVolumeHDF®

The Catalonian high-volume HDF study shows a significant 30% reduction in all-cause mortality for patients with HighVolumeHDF®.1 The estimated number needed to treat showed that to prevent one death per year eight patients would need to be switched from HighFlux HD to HighVolumeHDF®.

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1 Maduell F. et al., J Am Soc Nephrol (2013); 24: 487-497.

Fewer cardiovascular complications with HighVolumeHDF®

Multiple risk factors contribute jointly to cardiovascular diseases, which can lead to rapid progression of atherosclerosis and left ventricular hypertrophy. These cardiovascular diseases are also associated with decreased tolerability of haemodialysis and other complications.

Inflammation and increased β2-microglobulin levels are important risk factors, which should be efficiently reduced during dialysis.

Reduction of ß2-microglobulin

Graph showing serum β2 microglobulin

A large number of retained compounds are involved in uraemic toxicity. Among them are larger solutes and protein-bound compounds which seem to be associated with deleterious biological and clinical effects, but are difficult to remove by dialysis. Increased serum ß2-m levels are related to higher mortality.1

Results from a subgroup of patients from the CONvective TRAnsport STudy (CONTRAST) study show that after 6 months pre-dialytic serum ß2-m levels were decreased significantly in patients with HDF.2

1 Cheung A. et al., J Am Soc Nephrol (2006); 17: 546-555.
2 Penne L. et al., Clin J Am Soc Nephrol (2010); 5: 80-86.

Reduction of inflammation

A diagram showing the evaluation of inflammation status

Inflammation is an important cardiovascular risk factor for dialysis patients. Serum levels of inflammatory markers such as cytokines and C-reactive protein (CRP) are higher in these patients than in the general population. CRP has been identified as a predictor of all-cause and cardiovascular mortality in patients on haemodialysis.1

Patients being treated with online HDF benefit from significantly lower levels of CRP than patients on Low-Flux HD.2

1 Panichi P. et al., Nephrol Dial Transplant (2008); 23: 2337-2343.
2 Pedrini L. et al., Nephrol Dial Transplant (2011); 26 : 2617-2624.